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Details on Person Expression of ZAP70 and other components of the TCR signalin...
| Class:Id | Summation:9850802 |
|---|---|
| _displayName | Expression of ZAP70 and other components of the TCR signalin... |
| _timestamp | 2023-10-12 18:29:58 |
| created | [InstanceEdit:9850804] Rothfels, Karen, 2023-10-12 |
| text | Expression of ZAP70 and other components of the TCR signaling pathway such as LAT, SLP76 and CD3 are downregulated by NPM1-ALK in a kinase dependent fashion. Repression of ZAP70 depends on STAT3 and DNMT1 and is coincident with increased methylation of 8 CpG islands in the intron 1- exon 2 boundary region (Ambrogio et al, 2009). Although STAT3 is known to induce hypermethylation of target genes by binding and recruiting DNMT1, in the case of ZAP70, neither direct binding of STAT3 to the ZAP70 promoter nor a direct interaction of STAT3 and DNMT1 has been demonstrated (Ambrogio et al, 2009; Zhang et al, 2005; Zhang et al, 2007). |
| (summation) | [BlackBoxEvent:9851133] STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing [Homo sapiens] |
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No pathways have been reviewed or authored by Expression of ZAP70 and other components of the TCR signalin... (9850802)
