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Details on Person The JAK family member TYK2 is phosphorylated in anaplastic l...
| Class:Id | Summation:9850797 |
|---|---|
| _displayName | The JAK family member TYK2 is phosphorylated in anaplastic l... |
| _timestamp | 2023-10-12 18:29:58 |
| created | [InstanceEdit:9850804] Rothfels, Karen, 2023-10-12 |
| text | The JAK family member TYK2 is phosphorylated in anaplastic large cell lymphoma (ALCL) in both NPM1-ALK positive and ALK- cases. TYK2 phosphorylation promotes phosphorylation of both STAT1 and STAT3, although direct TYK2-mediated phosphorylation has not been demonstrated. Active TYK2 additionally contributes to increased expression of the pro-survival gene MCL1,. Consistent with this, knockdown of TYK2 induces death in human ALCL cell lines (Prutsch et al, 2019). |
| (summation) | [Reaction:9851114] NPM1-ALK-dependent TYK2 phosphorylation [Homo sapiens] |
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No pathways have been reviewed or authored by The JAK family member TYK2 is phosphorylated in anaplastic l... (9850797)
