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Details on Person GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4

Class:Id	Reaction:9846552
_displayName	GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
_timestamp	2023-10-11 22:24:55
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9846550] D'Eustachio, Peter, 2023-10-11
input	[EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:175954] TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 [LiteratureReference:1225903] Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors [LiteratureReference:202606] Structural basis of Smad1 activation by receptor kinase phosphorylation [LiteratureReference:208376] Structural basis of heteromeric smad protein assembly in TGF-beta signaling [LiteratureReference:208162] Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. [LiteratureReference:3009206] Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling
name	GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
negativePrecedingEvent	[NegativePrecedingEvent:9754412] Futile Cycle: USP9X (FAM) deubiquitinates SMAD4
output	[DefinedSet:171175] p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:170868] Activated type I receptor phosphorylates SMAD2/3 directly [Homo sapiens] [Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens] [Reaction:1181156] Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL [Homo sapiens] [Reaction:1225894] Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL [Homo sapiens] [Reaction:1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Homo sapiens] [Reaction:1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin [Homo sapiens] [Reaction:2470508] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846587] R-HSA-9846552.1
summation	[Summation:176014] The phosphorylated C-terminal tail of R-SMAD induces a confo...
(hasEvent)	[Pathway:9846544] GOCAM SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:9846538] GOCAM WWTR1 binds SMAD2/3:SMAD4 heterotrimer [Homo sapiens] [BlackBoxEvent:9846551] GOCAM The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (9846552)