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Details on Person GOCAM The SMAD2/3:SMAD4 complex transfers to the nucleus

Class:Id	BlackBoxEvent:9846551
_displayName	GOCAM The SMAD2/3:SMAD4 complex transfers to the nucleus
_timestamp	2023-10-11 22:24:55
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9846550] D'Eustachio, Peter, 2023-10-11
input	[DefinedSet:171175] p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:173516] The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation [LiteratureReference:178148] Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner [LiteratureReference:178143] An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity [LiteratureReference:208381] Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads [LiteratureReference:2584304] Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling [LiteratureReference:2584303] Nucleocytoplasmic shuttling of Smad proteins
name	GOCAM The SMAD2/3:SMAD4 complex transfers to the nucleus
output	[DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9846552] GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens] [Reaction:1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Homo sapiens]
regulatedBy	[NegativeRegulation:9732720] Negative regulation by 'p-T,Y MAPK dimers [cytosol]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846578] R-HSA-9846551.1
summation	[Summation:176008] The phosphorylated R-SMAD:CO-SMAD complex rapidly translocat...
(hasEvent)	[Pathway:9846544] GOCAM SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:9846539] GOCAM SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Homo sapiens] [Reaction:9846542] GOCAM SMAD2/3:SMAD4 heterotrimer binds SP1 [Homo sapiens] [Reaction:9846547] GOCAM p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter [Homo sapiens] [BlackBoxEvent:9846549] GOCAM FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 [Homo sapiens] [Reaction:9846557] GOCAM MEN1 binds SMAD2/3:SMAD4 heterotrimer [Homo sapiens] [Reaction:9846558] GOCAM Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Homo sapiens] [Reaction:9846561] GOCAM YBX1 binds COL1A2 gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM The SMAD2/3:SMAD4 complex transfers to the nucleus (9846551)