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Details on Person GOCAM WWTR1 binds SMAD2/3:SMAD4 heterotrimer

Class:Id	Reaction:9846538
_displayName	GOCAM WWTR1 binds SMAD2/3:SMAD4 heterotrimer
_timestamp	2023-10-11 22:24:54
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9846550] D'Eustachio, Peter, 2023-10-11
input	[DefinedSet:171175] p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1629773] WWTR1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
name	GOCAM WWTR1 binds SMAD2/3:SMAD4 heterotrimer
output	[Complex:2031357] WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9846552] GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens] [Reaction:1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846572] R-HSA-9846538.1
summation	[Summation:2031343] In the cytosol of human embryonic stem cells, WWTR1 (TAZ) bi...
(hasEvent)	[Pathway:9846544] GOCAM SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9846562] GOCAM WWTR1:SMAD translocates to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM WWTR1 binds SMAD2/3:SMAD4 heterotrimer (9846538)