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Details on Person GOCAM Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

Class:IdReaction:9846413
_displayNameGOCAM Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
_timestamp2023-10-26 14:58:11
catalystActivity[CatalystActivity:9851506] ubiquitin ligase activator activity of Beta-Pix:CDC42:GTP [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input[Complex:182917] Beta-Pix:CDC42:GTP [cytosol] [Homo sapiens]
[Complex:182917] Beta-Pix:CDC42:GTP [cytosol] [Homo sapiens]
[Complex:182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:182989] Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
modified[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
[InstanceEdit:9851507] D'Eustachio, Peter, 2023-10-26
nameGOCAM Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
Beta-Pix pushes CIN85 away from CBL
output[Complex:8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846448] R-HSA-9846413.1
structureModified[InstanceEdit:9851507] D'Eustachio, Peter, 2023-10-26
summation[Summation:183092] High concentrations of active CDC42 (bound to GTP) and Beta-...
(hasEvent)[Pathway:9846353] GOCAM EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:9846370] GOCAM CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (9846413)
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