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Query author contributions in Reactome

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Details on Person GOCAM EGFR binds EGF ligand

Class:IdReaction:9846408
_displayNameGOCAM EGFR binds EGF ligand
_timestamp2023-10-12 21:22:06
catalystActivity[CatalystActivity:9851161] receptor ligand activity of EGF-like ligands [extracellular region]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input[EntityWithAccessionedSequence:179837] EGFR [plasma membrane] [Homo sapiens]
[DefinedSet:9624194] EGF-like ligands [extracellular region] [Homo sapiens]
literatureReference[LiteratureReference:188642] Activation of epidermal growth factor receptor by epidermal growth factor
modified[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
[InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
nameGOCAM EGFR binds EGF ligand
output[Complex:9624419] EGFR:EGF-like ligands [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:204695] Negative regulation by 'LRIG1 [plasma membrane]'
regulationReference[RegulationReference:9642127] Negative regulation by 'LRIG1 [plasma membrane]' A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846442] R-HSA-9846408.1
structureModified[InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
summation[Summation:188443] The prototypic receptor tyrosine kinase (RTK) EGFR is compos...
(hasEvent)[Pathway:9846354] GOCAM Signaling by EGFR [Homo sapiens]
(precedingEvent)[Reaction:9846387] GOCAM EGFR dimerization [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM EGFR binds EGF ligand (9846408)
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