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Details on Person GOCAM EGFR activates PLC-gamma1 by phosphorylation

Class:Id	Reaction:9846406
_displayName	GOCAM EGFR activates PLC-gamma1 by phosphorylation
_timestamp	2023-10-20 21:33:41
catalystActivity	[CatalystActivity:9851169] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input	[Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851167] D'Eustachio, Peter, 2023-10-12 [InstanceEdit:9851295] D'Eustachio, Peter, 2023-10-20
name	GOCAM EGFR activates PLC-gamma1 by phosphorylation ATP + L-tyrosyl-(protein) => ADP + H(+) + O-phospho-L-tyrosyl-(protein)
output	[Complex:212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9846379] GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens] [Reaction:9846388] GOCAM Phosphorylation of EGFR by SRC kinase [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846465] R-HSA-9846406.1
structureModified	[InstanceEdit:9851167] D'Eustachio, Peter, 2023-10-12 [InstanceEdit:9851295] D'Eustachio, Peter, 2023-10-20
summation	[Summation:213064] EGFR phosphorylates PLC-gamma1, thus activating it.
(hasEvent)	[Pathway:9846352] GOCAM EGFR interacts with phospholipase C-gamma [Homo sapiens]
(precedingEvent)	[Reaction:9846397] GOCAM Active PLC-gamma1 dissociates from EGFR [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM EGFR activates PLC-gamma1 by phosphorylation (9846406)