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Details on Person GOCAM SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)

Class:Id	Reaction:9846404
_displayName	GOCAM SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
_timestamp	2023-10-10 21:23:55
catalystActivity	[CatalystActivity:177932] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
figure	[Figure:179426] /figures/sos_acts_ras.jpg
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
name	GOCAM SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9846377] GOCAM GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens] [Reaction:9846384] GOCAM GRB2-1 binds SOS1 [Homo sapiens] [Reaction:9846399] GOCAM EGFR autophosphorylation [Homo sapiens] [Reaction:9846388] GOCAM Phosphorylation of EGFR by SRC kinase [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846461] R-HSA-9846404.1
summation	[Summation:188440] The guanine nucleotide exchange factor SOS1 interacts with E...
(hasEvent)	[Pathway:9846356] GOCAM GRB2 events in EGFR signaling [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (9846404)