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Details on Person GOCAM Assembly of EGFR complex in clathrin-coated vesicles

Class:IdReaction:9846403
_displayNameGOCAM Assembly of EGFR complex in clathrin-coated vesicles
_timestamp2023-10-26 14:58:09
catalystActivity[CatalystActivity:9851505] protein-macromolecule adaptor activity of CIN85:endophilin [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input[Complex:182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] [Homo sapiens]
[Complex:8875480] CIN85:endophilin [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:183056] Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
modified[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
[InstanceEdit:9851507] D'Eustachio, Peter, 2023-10-26
nameGOCAM Assembly of EGFR complex in clathrin-coated vesicles
output[Complex:182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846450] R-HSA-9846403.1
structureModified[InstanceEdit:9851507] D'Eustachio, Peter, 2023-10-26
summation[Summation:183099] CBL-CIN85-Endophilin complex mediates ligand-induced down-re...
(hasEvent)[Pathway:9846353] GOCAM EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:9846392] GOCAM EGFR binds EPS15, EPN1, EPS15L1 [Homo sapiens]
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