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Details on Person GOCAM Active PLC-gamma1 dissociates from EGFR

Class:Id	Reaction:9846397
_displayName	GOCAM Active PLC-gamma1 dissociates from EGFR
_timestamp	2023-10-12 21:22:05
catalystActivity	[CatalystActivity:9851156] transmembrane receptor protein tyrosine kinase activity of EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input	[Complex:212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
name	GOCAM Active PLC-gamma1 dissociates from EGFR
output	[EntityWithAccessionedSequence:167679] p-4Y-PLCG1 [plasma membrane] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846406] GOCAM EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens] [Reaction:9846379] GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846439] R-HSA-9846397.1
structureModified	[InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
summation	[Summation:213061] Once activated PLC-gamma1 dissociates from EGFR, it can hydr...
(hasEvent)	[Pathway:9846352] GOCAM EGFR interacts with phospholipase C-gamma [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Active PLC-gamma1 dissociates from EGFR (9846397)