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Details on Person GOCAM EGFR phosphorylates EPS15

Class:IdReaction:9846396
_displayNameGOCAM EGFR phosphorylates EPS15
_timestamp2023-10-24 22:59:25
catalystActivity[CatalystActivity:8867039] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input[Complex:8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:8866989] Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis
[LiteratureReference:8866987] Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment
[LiteratureReference:8866997] Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation
[LiteratureReference:8867017] Eps15: a multifunctional adaptor protein regulating intracellular trafficking
modified[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
[InstanceEdit:9851400] D'Eustachio, Peter, 2023-10-24
nameGOCAM EGFR phosphorylates EPS15
ATP + L-tyrosyl-(protein) => ADP + H(+) + O-phospho-L-tyrosyl-(protein)
output[Complex:8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846462] R-HSA-9846396.1
structureModified[InstanceEdit:9851400] D'Eustachio, Peter, 2023-10-24
summation[Summation:8867040] EPS15 is phosphorylated at Y849 by activated EGFR (Confaloni...
(hasEvent)[Pathway:9846353] GOCAM EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:9846374] GOCAM PTPN3 dephosphorylates EPS15 [Homo sapiens]
[Reaction:9846386] GOCAM Activated EGFR binds clathrin and AP-2 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM EGFR phosphorylates EPS15 (9846396)