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Details on Person GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1

Class:Id	Reaction:9846385
_displayName	GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1
_timestamp	2023-10-13 16:54:09
catalystActivity	[CatalystActivity:9851192] signaling adaptor activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
figure	[Figure:179452] /figures/pi3k_cat_unit_binds.jpg
input	[Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling [LiteratureReference:179884] Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851197] D'Eustachio, Peter, 2023-10-13
name	GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1
output	[Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846400] GOCAM GAB1 phosphorylation by EGFR kinase [Homo sapiens] [Reaction:9846416] GOCAM GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846433] R-HSA-9846385.1
structureModified	[InstanceEdit:9851197] D'Eustachio, Peter, 2023-10-13
summation	[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...
(hasEvent)	[Pathway:9846355] GOCAM GAB1 signalosome [Homo sapiens]
(precedingEvent)	[Reaction:9846394] GOCAM PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM PI3K binds to EGF:EGFR:GRB2:GAB1 (9846385)