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Details on Person GOCAM Phosphorylation of CBL (EGFR:CBL)

Class:Id	Reaction:9846381
_displayName	GOCAM Phosphorylation of CBL (EGFR:CBL)
_timestamp	2023-10-24 22:59:32
catalystActivity	[CatalystActivity:183047] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input	[Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:183081] Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation [LiteratureReference:183048] Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851341] D'Eustachio, Peter, 2023-10-23 [InstanceEdit:9851400] D'Eustachio, Peter, 2023-10-24
name	GOCAM Phosphorylation of CBL (EGFR:CBL) ATP + L-tyrosyl-(protein) => ADP + H(+) + O-phospho-L-tyrosyl-(protein)
output	[Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9846375] GOCAM Binding of CBL to EGFR [Homo sapiens] [Reaction:9846399] GOCAM EGFR autophosphorylation [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846449] R-HSA-9846381.1
structureModified	[InstanceEdit:9851400] D'Eustachio, Peter, 2023-10-24
summation	[Summation:182991] EGF (and indeed FGF, PDGF and NGF) stimulation results in CB...
(hasEvent)	[Pathway:9846353] GOCAM EGFR downregulation [Homo sapiens]
(precedingEvent)	[Reaction:9846376] GOCAM Ubiquitination of stimulated EGFR (CBL) [Homo sapiens] [Reaction:9846401] GOCAM CBL binds and ubiquitinates phosphorylated Sprouty [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Phosphorylation of CBL (EGFR:CBL) (9846381)