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Details on Person GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor

Class:Id	Reaction:9846379
_displayName	GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor
_timestamp	2023-10-12 21:22:10
catalystActivity	[CatalystActivity:9851164] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input	[EntityWithAccessionedSequence:202320] PLCG1 [cytosol] [Homo sapiens] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212712] Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
name	GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor
output	[Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846388] GOCAM Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:9846387] GOCAM EGFR dimerization [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846420] R-HSA-9846379.1
structureModified	[InstanceEdit:9851160] D'Eustachio, Peter, 2023-10-12
summation	[Summation:213065] Inactive phospholipase C-gamma1 (PLCG1) binds to activated e...
(hasEvent)	[Pathway:9846352] GOCAM EGFR interacts with phospholipase C-gamma [Homo sapiens]
(precedingEvent)	[Reaction:9846406] GOCAM EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Phospholipase C-gamma1 binds to the activated EGF receptor (9846379)