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Details on Person GOCAM SHC1 phosphorylation by phosphorylated EGFR

Class:Id	Reaction:9846372
_displayName	GOCAM SHC1 phosphorylation by phosphorylated EGFR
_timestamp	2023-10-23 20:53:49
catalystActivity	[CatalystActivity:9624433] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
figure	[Figure:179445] /figures/egfr_phos_of_shc_.jpg
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:180308] Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites [LiteratureReference:180313] Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851295] D'Eustachio, Peter, 2023-10-20 [InstanceEdit:9851340] D'Eustachio, Peter, 2023-10-23
name	GOCAM SHC1 phosphorylation by phosphorylated EGFR ATP + L-tyrosyl-(protein) => ADP + H(+) + O-phospho-L-tyrosyl-(protein)
output	[Complex:180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9846414] GOCAM SHC1 binds to the phosphorylated EGF receptor:ligand complex [Homo sapiens] [Reaction:9846399] GOCAM EGFR autophosphorylation [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846431] R-HSA-9846372.1
structureModified	[InstanceEdit:9851295] D'Eustachio, Peter, 2023-10-20
summation	[Summation:188540] Once bound to EGFR, SHC1 is phosphorylated on two tyrosines ...
(hasEvent)	[Pathway:9846350] GOCAM SHC1 events in EGFR signaling [Homo sapiens]
(precedingEvent)	[Reaction:9846417] GOCAM GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SHC1 phosphorylation by phosphorylated EGFR (9846372)