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Details on Person GOCAM PTPRK dephosphorylates p-6Y-EGFR

Class:Id	Reaction:9846371
_displayName	GOCAM PTPRK dephosphorylates p-6Y-EGFR
_timestamp	2023-10-24 22:59:30
catalystActivity	[CatalystActivity:6785698] protein tyrosine phosphatase activity of PTPRK [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6785333] An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis [LiteratureReference:6785337] Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
modified	[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10 [InstanceEdit:9851400] D'Eustachio, Peter, 2023-10-24
name	GOCAM PTPRK dephosphorylates p-6Y-EGFR H2O + O-phospho-L-tyrosyl-(protein) => L-tyrosyl-(protein) + phosphate
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:9624420] EGF-like ligands:EGFR dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846388] GOCAM Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:9846387] GOCAM EGFR dimerization [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846440] R-HSA-9846371.1
summation	[Summation:6785702] Receptor-type tyrosine-protein phosphatase kappa (PTPRK/RPTP...
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No pathways have been reviewed or authored by GOCAM PTPRK dephosphorylates p-6Y-EGFR (9846371)