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Details on Person GOCAM CBL-mediated ubiquitination of CIN85

Class:IdReaction:9846366
_displayNameGOCAM CBL-mediated ubiquitination of CIN85
_timestamp2023-10-10 21:23:36
catalystActivity[CatalystActivity:183057] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9846405] D'Eustachio, Peter, 2023-10-10
input[Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:188579] Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors
modified[InstanceEdit:9846469] D'Eustachio, Peter, 2023-10-10
nameGOCAM CBL-mediated ubiquitination of CIN85
output[Complex:182936] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846453] R-HSA-9846366.1
summation[Summation:188573] The adaptor protein CIN85 is monoubiquitinated by CBL after ...
(hasEvent)[Pathway:9846353] GOCAM EGFR downregulation [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM CBL-mediated ubiquitination of CIN85 (9846366)
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