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Details on Person GOCAM SMAD3 binds STUB1 (CHIP)

Class:IdReaction:9846259
_displayNameGOCAM SMAD3 binds STUB1 (CHIP)
_doReleaseFALSE
_timestamp2023-10-09 23:12:40
compartment[Compartment:70101] cytosol
created[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
input[EntityWithAccessionedSequence:170855] SMAD3 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:975970] STUB1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2187374] CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription
[LiteratureReference:2187378] CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
modified[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
nameGOCAM SMAD3 binds STUB1 (CHIP)
output[Complex:2187365] SMAD3:STUB1 [cytosol] [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846283] R-HSA-9846259.1
summation[Summation:2187385] STUB1 (CHIP), an E3 ubiquitin ligase, binds SMAD3 irrespecti...
(hasEvent)[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)[Reaction:9846246] GOCAM STUB1 (CHIP) ubiquitinates SMAD3 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SMAD3 binds STUB1 (CHIP) (9846259)
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