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Details on Person GOCAM MTMR4 binds phosphorylated SMAD2/3

Class:Id	Reaction:9846253
_displayName	GOCAM MTMR4 binds phosphorylated SMAD2/3
_doRelease	FALSE
_timestamp	2023-10-09 23:12:32
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane
created	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
input	[DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2187404] MTMR4 [early endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2187402] MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes
modified	[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
name	GOCAM MTMR4 binds phosphorylated SMAD2/3
output	[Complex:2187399] p-2S-SMAD2/3:MTMR4 [early endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9846190] GOCAM Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:9846193] GOCAM Activated type I receptor phosphorylates SMAD2/3 directly [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846289] R-HSA-9846253.1
summation	[Summation:2187400] A protein phosphatase MTMR4, residing in the early endosome ...
(hasEvent)	[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:9846254] GOCAM MTMR4 dephosphorylates SMAD2/3 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM MTMR4 binds phosphorylated SMAD2/3 (9846253)