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Details on Person GOCAM SMAD7 binds to SMURF1

Class:Id	Reaction:9846252
_displayName	GOCAM SMAD7 binds to SMURF1
_doRelease	FALSE
_timestamp	2023-10-09 23:12:42
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
inferredFrom	[Reaction:2169004] Smad7 binds SMURF1 [Homo sapiens]
input	[EntityWithAccessionedSequence:178197] SMAD7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3004548] SMURF1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:178198] Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7 [LiteratureReference:2168995] Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity [LiteratureReference:178173] Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
modified	[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
name	GOCAM SMAD7 binds to SMURF1
output	[Complex:2167913] SMAD7:SMURF1 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens] [Reaction:9736970] WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter [Homo sapiens] [Reaction:5252001] ATP1B4 binds SNW1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846286] R-HSA-9846252.1
summation	[Summation:2167915] SMAD7 binds to SMURF1 in the nucleus (Ebisawa et al. 2001, T...
(hasEvent)	[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:9846248] GOCAM SMAD7:SMURF1 complex binds XPO1 (CRM1) [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SMAD7 binds to SMURF1 (9846252)