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Details on Person GOCAM STUB1 (CHIP) ubiquitinates SMAD3

Class:IdReaction:9846246
_displayNameGOCAM STUB1 (CHIP) ubiquitinates SMAD3
_doReleaseFALSE
_timestamp2023-10-09 23:12:59
catalystActivity[CatalystActivity:2187377] ubiquitin-protein transferase activity of SMAD3:STUB1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
input[Complex:2187365] SMAD3:STUB1 [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2187378] CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
[LiteratureReference:2187374] CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription
modified[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
nameGOCAM STUB1 (CHIP) ubiquitinates SMAD3
output[Complex:2187371] Ub-SMAD3 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:975970] STUB1 [cytosol] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846262] R-HSA-9846246.1
summation[Summation:2187383] STUB1 (CHIP) ubiquitinates SMAD3 in the absence of TGF-beta ...
(hasEvent)[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9846245] GOCAM Degradation of ubiquitinated SMAD3 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM STUB1 (CHIP) ubiquitinates SMAD3 (9846246)
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