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Details on Person GOCAM SMAD7:SMURF2 complex translocates to the cytosol

Class:Id	Reaction:9846242
_displayName	GOCAM SMAD7:SMURF2 complex translocates to the cytosol
_doRelease	FALSE
_timestamp	2023-10-09 23:12:51
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
inferredFrom	[Reaction:2167888] Smad7:SMURF2 complex translocates to the cytosol [Homo sapiens]
input	[Complex:2167870] SMAD7:SMURF2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:178228] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
modified	[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
name	GOCAM SMAD7:SMURF2 complex translocates to the cytosol
output	[Complex:2167883] SMAD7:SMURF2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9846247] GOCAM SMAD7 binds to SMURF2 [Homo sapiens] [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846263] R-HSA-9846242.1
summation	[Summation:2167865] After forming a complex in the nucleus, SMAD7:SMURF2 traffic...
(hasEvent)	[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:9846239] GOCAM SMAD7:SMURF complex binds to phosphorylated TGFBR1 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SMAD7:SMURF2 complex translocates to the cytosol (9846242)