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Details on Person GOCAM SMAD7:NEDD4L complex translocates to the cytosol

Class:Id	Reaction:9846235
_displayName	GOCAM SMAD7:NEDD4L complex translocates to the cytosol
_doRelease	FALSE
_timestamp	2023-10-09 23:12:46
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
inferredFrom	[Reaction:2176428] Translocation of Smad7:NEDD4L complex to the cytosol [Homo sapiens]
input	[Complex:2176418] SMAD7:NEDD4L [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2176422] NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
modified	[InstanceEdit:9846290] D'Eustachio, Peter, 2023-10-09
name	GOCAM SMAD7:NEDD4L complex translocates to the cytosol
output	[Complex:2176419] SMAD7:NEDD4L [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9846238] GOCAM NEDD4L ubiquitin ligase binds SMAD7 [Homo sapiens] [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846264] R-HSA-9846235.1
summation	[Summation:2176436] Binding of NEDD4L promotes translocation of SMAD7 to the cyt...
(hasEvent)	[Pathway:9846195] GOCAM Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:9846239] GOCAM SMAD7:SMURF complex binds to phosphorylated TGFBR1 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM SMAD7:NEDD4L complex translocates to the cytosol (9846235)