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Details on Person GOCAM Latent TGF-beta-1 binds integrins

Class:Id	Reaction:9846207
_displayName	GOCAM Latent TGF-beta-1 binds integrins
_doRelease	FALSE
_timestamp	2023-10-09 23:11:53
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input	[DefinedSet:2396176] LAP1 binding-integrins [plasma membrane] [Homo sapiens] [Complex:9737594] LTBP1:TGFB1:LAP1 [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2395368] Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1 [LiteratureReference:2395371] The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis [LiteratureReference:2395234] The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 [LiteratureReference:2395246] The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1 [LiteratureReference:2395309] Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1
modified	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
name	GOCAM Latent TGF-beta-1 binds integrins
output	[Complex:2396201] LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846189] GOCAM LTBP1, LTBP3 bind TGF-Beta [Homo sapiens] [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 [Homo sapiens] [BlackBoxEvent:9736810] Secretion and activation of the latent large complex of TGF-beta-3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846224] R-HSA-9846207.1
summation	[Summation:2395334] The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences ...
(hasEvent)	[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Latent TGF-beta-1 binds integrins (9846207)