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Details on Person GOCAM Secretion and activation of the latent large complex of TGF-beta-3

Class:IdBlackBoxEvent:9846204
_displayNameGOCAM Secretion and activation of the latent large complex of TGF-beta-3
_doReleaseFALSE
_timestamp2023-10-09 23:12:05
compartment[Compartment:17963] Golgi lumen
[Compartment:984] extracellular region
created[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input[Complex:9729952] TGF-beta-3:LAP3 [Golgi lumen] [Homo sapiens]
literatureReference[LiteratureReference:9737414] Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3
[LiteratureReference:9737431] Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding
[LiteratureReference:9737436] Latent transforming growth factor-beta is present in the extracellular matrix of embryonic hearts in situ
modified[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
nameGOCAM Secretion and activation of the latent large complex of TGF-beta-3
output[Complex:2395241] TGFB3:LAP3 [extracellular region] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9846230] R-HSA-9846204.1
summation[Summation:9737417] Similar to TGFB1, TGFB3 is also secreted as a latent large c...
(hasEvent)[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
(precedingEvent)[Reaction:9846182] GOCAM Latent TGF-beta-3 binds integrins [Homo sapiens]
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