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Details on Person GOCAM Phosphorylated SMAD2/3 dissociates from TGFBR

Class:Id	Reaction:9846190
_displayName	GOCAM Phosphorylated SMAD2/3 dissociates from TGFBR
_doRelease	FALSE
_timestamp	2023-10-09 23:12:01
compartment	[Compartment:17941] early endosome
created	[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input	[Complex:171180] TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:177257] MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling [LiteratureReference:175954] TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 [LiteratureReference:177255] Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling [LiteratureReference:208376] Structural basis of heteromeric smad protein assembly in TGF-beta signaling
modified	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
name	GOCAM Phosphorylated SMAD2/3 dissociates from TGFBR
output	[Complex:171173] TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9846193] GOCAM Activated type I receptor phosphorylates SMAD2/3 directly [Homo sapiens] [Reaction:9846201] GOCAM An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846229] R-HSA-9846190.1
summation	[Summation:176005] Upon phosphorylation of the R-SMAD (SMAD2/3), the conformati...
(hasEvent)	[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
(precedingEvent)	[Reaction:9846183] GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [Reaction:9846241] GOCAM PMEPA1 sequesters phosphorylated SMAD2/3 [Homo sapiens] [Reaction:9846253] GOCAM MTMR4 binds phosphorylated SMAD2/3 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Phosphorylated SMAD2/3 dissociates from TGFBR (9846190)