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Details on Person GOCAM LTBP1, LTBP3 bind TGF-Beta

Class:Id	Reaction:9846189
_displayName	GOCAM LTBP1, LTBP3 bind TGF-Beta
_doRelease	FALSE
_timestamp	2023-10-09 23:11:50
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input	[DefinedSet:2395372] LTBP1, LTBP3 [extracellular region] [Homo sapiens] [DefinedSet:2395372] LTBP1, LTBP3 [extracellular region] [Homo sapiens] [DefinedSet:2395372] LTBP1, LTBP3 [extracellular region] [Homo sapiens] [DefinedSet:2395330] TGFB:LAP [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2395251] Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta
modified	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
name	GOCAM LTBP1, LTBP3 bind TGF-Beta
output	[DefinedSet:2395250] LTBP1,LTBP3:TGFB:LAP [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 [Homo sapiens] [Reaction:170844] Latent TGF-beta-1 is cleaved by FURIN [Homo sapiens] [BlackBoxEvent:9736810] Secretion and activation of the latent large complex of TGF-beta-3 [Homo sapiens] [Reaction:9729941] Latent TGF-beta-3 is cleaved by FURIN [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846218] R-HSA-9846189.1
summation	[Summation:2395335] Transforming growth factor beta (TGF-beta) is a family of th...
(hasEvent)	[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
(precedingEvent)	[Reaction:9846207] GOCAM Latent TGF-beta-1 binds integrins [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM LTBP1, LTBP3 bind TGF-Beta (9846189)