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Details on Person GOCAM CBL neddylates TGFBR2

Class:Id	Reaction:9846187
_displayName	GOCAM CBL neddylates TGFBR2
_doRelease	FALSE
_timestamp	2023-10-09 23:11:42
catalystActivity	[CatalystActivity:4332230] ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643988] ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane] c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input	[Complex:4332229] TGFBR2:CBL [plasma membrane] [Homo sapiens] [Complex:4419896] NEDD8-AcM-UBE2M [cytosol] [Homo sapiens] [Complex:4419896] NEDD8-AcM-UBE2M [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4332219] c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor
modified	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
name	GOCAM CBL neddylates TGFBR2
output	[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8951627] AcM-UBE2M [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8951627] AcM-UBE2M [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4332222] NEDD8-K556,K567-TGFBR2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9846198] GOCAM CBL binds TGFBR2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846231] R-HSA-9846187.1
summation	[Summation:4332284] CBL neddylates TGFBR2 on lysine residues K556 and K567. The ...
(hasEvent)	[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM CBL neddylates TGFBR2 (9846187)