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Details on Person GOCAM Latent TGF-beta-3 binds integrins

Class:Id	Reaction:9846182
_displayName	GOCAM Latent TGF-beta-3 binds integrins
_doRelease	FALSE
_timestamp	2023-10-09 23:11:57
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9846202] D'Eustachio, Peter, 2023-10-09
input	[Complex:2395241] TGFB3:LAP3 [extracellular region] [Homo sapiens] [DefinedSet:2396408] LAP3-binding integrins [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2395234] The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 [LiteratureReference:2395274] Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin ?v?8-mediated activation of TGF-?
modified	[InstanceEdit:9846244] D'Eustachio, Peter, 2023-10-09
name	GOCAM Latent TGF-beta-3 binds integrins
output	[Complex:2396121] TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9846204] GOCAM Secretion and activation of the latent large complex of TGF-beta-3 [Homo sapiens] [Reaction:9846194] GOCAM Latent TGF-beta-3 is cleaved by FURIN [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9846226] R-HSA-9846182.1
summation	[Summation:2396136] The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences ne...
(hasEvent)	[Pathway:9846196] GOCAM TGF-beta receptor signaling activates SMADs [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM Latent TGF-beta-3 binds integrins (9846182)