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Details on Person DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA

Class:Id	Reaction:9845308
_displayName	DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA
_doRelease	TRUE
_timestamp	2024-05-14 13:33:22
authored	[InstanceEdit:9844946] May, Bruce, 2023-09-24
catalystActivity	[CatalystActivity:9845352] DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9845345] May, Bruce, 2023-10-02
edited	[InstanceEdit:9844946] May, Bruce, 2023-09-24
inferredFrom	[Reaction:9845305] Dnmt3a:Dnmt3l in nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd11:Dnmt3a:Dnmt3l methylates cytosine in DNA [Mus musculus]
input	[Complex:3211736] Chromatin [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9845358] Evolutionally dynamic L1 regulation in embryonic stem cells
modified	[InstanceEdit:9851205] May, Bruce, 2023-10-14 [InstanceEdit:9909823] May, Bruce, 2024-05-14
name	DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA
output	[Complex:5334137] Chromatin with 5mC [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex [Homo sapiens] [BlackBoxEvent:5601897] MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events [Homo sapiens]
releaseDate	2024-06-15
requiredInputComponent	[EntityWithAccessionedSequence:914159] TEX15 [nucleoplasm] [Homo sapiens]
reviewed	[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14 [InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9845361] R-HSA-9845308.1
structureModified	[InstanceEdit:9851205] May, Bruce, 2023-10-14
summation	[Summation:9851201] A piRNA bound to PIWIL4 (HIWI2) interacts by base complement...
(hasEvent)	[Pathway:9845323] Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) [Homo sapiens]
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No pathways have been reviewed or authored by DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (9845308)