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Details on Person CLIP1-LTK fusion binds PI3K to activate AKT

Class:Id	BlackBoxEvent:9845032
_displayName	CLIP1-LTK fusion binds PI3K to activate AKT
_doRelease	TRUE
_timestamp	2024-03-04 17:22:10
authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9845036] Rothfels, Karen, 2023-09-26
disease	[Disease:1500689] cancer [Disease:1247848] non-small cell lung carcinoma
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[Complex:9842603] CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer [plasma membrane] [Homo sapiens] [Complex:74693] PI3K [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9843214] Orlic-Milacic, Marija, 2023-09-06
isChimeric	FALSE
literatureReference	[LiteratureReference:9842438] The CLIP1-LTK fusion is an oncogenic driver�in non-small-cell lung cancer
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9852939] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08 [InstanceEdit:9862075] Rothfels, Karen, 2024-02-22 [InstanceEdit:9863625] Rothfels, Karen, 2024-03-04
name	CLIP1-LTK fusion binds PI3K to activate AKT
output	[Complex:9845029] CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9842667] CLIP1-LTK fusion autophosphorylates [Homo sapiens] [Reaction:9842659] CLIP1(1-1083)-LTK(488-864) fusion dimerizes [Homo sapiens]
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9845038] R-HSA-9845032.1
summation	[Summation:9845017] Activated CLIP1-LTK promotes phosphorylation of AKT at serin...
(hasEvent)	[Pathway:9842640] Signaling by LTK in cancer [Homo sapiens]
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No pathways have been reviewed or authored by CLIP1-LTK fusion binds PI3K to activate AKT (9845032)