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Details on Person Based on mouse studies, EBF2 transcription factor promotes b...

Class:IdSummation:9844893
_displayNameBased on mouse studies, EBF2 transcription factor promotes b...
_timestamp2023-10-02 17:44:30
created[InstanceEdit:9844894] Orlic-Milacic, Marija, 2023-09-23
literatureReference[LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity
[LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex
[LiteratureReference:9844613] Ebf2 is a selective marker of brown and beige adipogenic precursor cells
[LiteratureReference:9844394] ZFP423 controls EBF2 coactivator recruitment and PPARĪ³ occupancy to determine the thermogenic plasticity of adipocytes
[LiteratureReference:9844390] Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program
[LiteratureReference:9844687] BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
[LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation
[LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation
[LiteratureReference:9844614] EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
[LiteratureReference:9844565] Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis
[LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism
[LiteratureReference:9844638] Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
modified[InstanceEdit:9844898] Orlic-Milacic, Marija, 2023-09-23
[InstanceEdit:9844899] Orlic-Milacic, Marija, 2023-09-23
[InstanceEdit:9845442] Orlic-Milacic, Marija, 2023-10-02
textBased on mouse studies, EBF2 transcription factor promotes brown/beige adipogenesis by binding to EBF consensus sites in the regulatory sequences of target genes. In mouse brown and beige lineages, direct EBF2 binding has been demonstrated for PRDM16 gene (Rajakumari et al. 2013), PPARA gene (Shapira et al. 2017; Shao et al. 2021), and UCP1 gene (Shapira et al. 2017; Liu et al. 2020; Shao et al. 2021). Several other genes are annotated as candidate EBF2 target genes because they were shown in multiple studies to be positively regulated by EBF2 but binding of EBF2 to their regulatory sequences has not been explicitly reported. Candidate EBF2 target genes are CIDEA (Rajakumari et al. 2013; Wang et al. 2014; Zhao et al. 2014; Stine et al. 2016; Brunmeir et al. 2016; Shapira et al. 2017; Pearson et al. 2019), COX7A1 (Rajakumari et al. 2013; Wang et al. 2014; Zhao et al. 2014; Stine et al. 2016; Shapira et al. 2017), DIO2 (Rajakumari et al. 2013; Zhao et al. 2014; Shao et al. 2016; Mi et al. 2017; Shapira et al. 2017; Patil et al. 2017; Pearson et al. 2019; Shao et al. 2021), ELOVL3 (Shao et al. 2016; Mi et al. 2017; Liu et al. 2020), and PPARGC1A (Rajakumari et al. 2013; Wang et al. 2014; Zhao et al. 2014; Stine et al. 2016; Mi et al. 2017; Shapira et al. 2017).
(summation)[Reaction:9844366] EBF2 binds target gene loci [Homo sapiens]
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