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Details on Person Ppargc1a gene expression is positively regulated by Ebf2 and Pparg

Class:Id	BlackBoxEvent:9844841
_displayName	Ppargc1a gene expression is positively regulated by Ebf2 and Pparg
_doRelease	TRUE
_timestamp	2024-03-06 02:45:55
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9844840] Orlic-Milacic, Marija, 2023-09-22
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
input	[EntityWithAccessionedSequence:5667085] Ppargc1a gene [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex [LiteratureReference:9844613] Ebf2 is a selective marker of brown and beige adipogenic precursor cells [LiteratureReference:9844614] EBF2 promotes the recruitment of beige adipocytes in white adipose tissue [LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism [LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation [LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation
modified	[InstanceEdit:9854549] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855095] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855222] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9860956] Orlic-Milacic, Marija, 2024-02-13 [InstanceEdit:9863933] Matthews, Lisa, 2024-03-06
name	Ppargc1a gene expression is positively regulated by Ebf2 and Pparg
output	[EntityWithAccessionedSequence:556791] Ppargc1a [nucleoplasm] [Mus musculus]
regulatedBy	[PositiveRegulation:9855025] Positive regulation by 'Activated Pparg:Rxra [nucleoplasm]' [PositiveRegulation:9855024] Positive regulation by 'Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863934] Chun, Tae-Hwa, 2023-12-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9844842] R-MMU-9844841.1
structureModified	[InstanceEdit:9855095] Orlic-Milacic, Marija, 2023-11-29
summation	[Summation:9844839] During brown and beige adipogenesis in mice, Ppargc1a gene e...
(inferredFrom)	[BlackBoxEvent:9844822] PPARGC1A gene expression is stimulated by EBF2 [Homo sapiens]
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