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Details on Person The HUSH complex bound to trimethylated histone H3 of retroe...

Class:IdSummation:9844749
_displayNameThe HUSH complex bound to trimethylated histone H3 of retroe...
_timestamp2024-05-14 13:40:18
created[InstanceEdit:9844754] May, Bruce, 2023-09-22
literatureReference[LiteratureReference:9844748] Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
[LiteratureReference:9844750] TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
modified[InstanceEdit:9851283] May, Bruce, 2023-10-16
[InstanceEdit:9856839] May, Bruce, 2023-12-23
[InstanceEdit:9909823] May, Bruce, 2024-05-14
textThe HUSH complex bound to trimethylated histone H3 of retroelement chromatin recruits the NEXT RNA degradation complex (RBM7:ZCCHC8:SKIV2L2) (inferred from mouse homologs in Garland et al. 2022). MPHOSPH8 (MPP8) of the HUSH complex binds ZCCHC8 close to the site on ZCCHC8 bound by SKIV2L2 (MTR4) (inferred from mouse homologs in Garland et al. 2022). NEXT and HUSH cooperate to repress expression of retroelements, with NEXT suppressing shorter, non-polyadenylated transcripts, likely through RNA degradation, and HUSH suppressing full-length polyadenylated transcripts, likely through repression of transcription (inferred from mouse homologs in Garland et al. 2022). The TASOR subunit of the HUSH complex contains a catalytically active PARP domain that is necessary for targeted H3K9me3 deposition and therefore may direct the HUSH complex to genomic targets (Douse et al. 2020).
(summation)[Reaction:9844716] MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex [Homo sapiens]
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