Query author contributions in Reactome
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Details on Person Both Periphilin (PPHLN1) (Castello et al. 2012, Seczynska et...
| Class:Id | Summation:9844746 |
|---|---|
| _displayName | Both Periphilin (PPHLN1) (Castello et al. 2012, Seczynska et... |
| _timestamp | 2023-10-22 07:42:31 |
| created | [InstanceEdit:9844754] May, Bruce, 2023-09-22 |
| literatureReference | [LiteratureReference:9844043] Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators [LiteratureReference:9844752] Periphilin self-association underpins epigenetic silencing by the HUSH complex |
| modified | [InstanceEdit:9851283] May, Bruce, 2023-10-16 [InstanceEdit:9851319] May, Bruce, 2023-10-22 |
| text | Both Periphilin (PPHLN1) (Castello et al. 2012, Seczynska et al. 2022) and TASOR (Queiroz et al. 2019, Douse et al. 2020) of the HUSH complex bind RNA. The HUSH complex binds transcripts from active LINE1 retroelements prior to transcriptional repression of those elements (Seczynska et al. 2022). Increased binding of the HUSH complex to LINE1 retroelements is observed upon transcription through the LINE1 retroelement (Liu et al. 2018). The C-terminal region of PPHLN1 binds TASOR and the N-terminal region self-aggregates and probably binds RNA (Prigozhin et al. 2020). |
| (summation) | [Reaction:9843990] HUSH complex binds LINE1 (L1) RNA [Homo sapiens] |
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No pathways have been reviewed or authored by Both Periphilin (PPHLN1) (Castello et al. 2012, Seczynska et... (9844746)
