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Details on Person In mouse beige and brown adipocyte lineages binding of Ebf2 ...
| Class:Id | Summation:9844690 |
|---|---|
| _displayName | In mouse beige and brown adipocyte lineages binding of Ebf2 ... |
| _timestamp | 2023-10-02 17:54:07 |
| created | [InstanceEdit:9844689] Orlic-Milacic, Marija, 2023-09-21 |
| modified | [InstanceEdit:9844899] Orlic-Milacic, Marija, 2023-09-23 [InstanceEdit:9845444] Orlic-Milacic, Marija, 2023-10-02 |
| text | In mouse beige and brown adipocyte lineages binding of Ebf2 transcription factor to Ebf sites within regulatory sequences of genes involved in brown/beige adipogenesis facilitates recruitment of Pparg to the nearby PPREs (peroxisome proliferator response elements). PPARG enhances EBF2-stimulated transcription of the brown/beige adipogenesis target genes: Ppara, Prdm16, and Ucp1 by directly binding to these gene loci (Rajakumari et al. 2013). Pparg binding to the Ucp1 gene locus was also reported in Angueira et al. 2020, and Liu et al. 2020. Pparg also binds to the Ebf2 target gene Ppargc1a (Pearson et al. 2019), which encodes brown/beige fat tissue-specific coactivator of Pparg, Pgc1alpha, but Pparg-mediated induction of Ppargc1a gene expression has not been tested. PPARG also binds to the regulatory region of the Cidea gene (Brunmeir et al. 2016), a candidate Ebf2 target, but Pparg-mediated induction of Cidea has not been tested. Ppargc1a and Cidea genes are annotated as candidate targets of Pparg in the context of prior Ebf2-mediated regulation of brown/beige adipogenesis genes. |
| (summation) | [BlackBoxEvent:9844700] Pparg binds Ebf2-bound gene loci [Mus musculus] |
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