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Details on Person Dio2 gene expression is stimulated by Ebf2 and repressed by Znf423 and NuRD

Class:Id	BlackBoxEvent:9844655
_displayName	Dio2 gene expression is stimulated by Ebf2 and repressed by Znf423 and NuRD
_doRelease	TRUE
_timestamp	2024-03-06 02:45:48
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9844653] Orlic-Milacic, Marija, 2023-09-21
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
input	[EntityWithAccessionedSequence:9854591] Dio2 gene [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism [LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation [LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation [LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex [LiteratureReference:9844394] ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes [LiteratureReference:9844390] Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program [LiteratureReference:9844638] Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
modified	[InstanceEdit:9854562] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855095] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855222] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9860956] Orlic-Milacic, Marija, 2024-02-13 [InstanceEdit:9863933] Matthews, Lisa, 2024-03-06
name	Dio2 gene expression is stimulated by Ebf2 and repressed by Znf423 and NuRD
output	[EntityWithAccessionedSequence:9855069] Dio2 [plasma membrane] [Mus musculus]
regulatedBy	[NegativeRegulation:9855020] Negative regulation by 'Znf423 [nucleoplasm]' [NegativeRegulation:9855023] Negative regulation by 'mNuRD complex [nucleoplasm]' [PositiveRegulation:9855025] Positive regulation by 'Activated Pparg:Rxra [nucleoplasm]' [PositiveRegulation:9855024] Positive regulation by 'Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863934] Chun, Tae-Hwa, 2023-12-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9844657] R-MMU-9844655.1
structureModified	[InstanceEdit:9855095] Orlic-Milacic, Marija, 2023-11-29
summation	[Summation:9844652] Based on mouse studies Dio2 is a candidate Ebf2 target gene,...
(inferredFrom)	[BlackBoxEvent:9844598] DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423 [Homo sapiens]
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