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Details on Person DIO2 gene encodes type II iodothyronine deiodinase, which is...
| Class:Id | Summation:9844649 |
|---|---|
| _displayName | DIO2 gene encodes type II iodothyronine deiodinase, which is... |
| _timestamp | 2025-09-10 08:03:32 |
| created | [InstanceEdit:9844648] Orlic-Milacic, Marija, 2023-09-21 |
| literatureReference | [LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism [LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation [LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation [LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex [LiteratureReference:9844394] ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes [LiteratureReference:9844390] Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program [LiteratureReference:9844638] Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning |
| modified | [InstanceEdit:9844796] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9844899] Orlic-Milacic, Marija, 2023-09-23 [InstanceEdit:9845455] Orlic-Milacic, Marija, 2023-10-02 [InstanceEdit:9845457] Orlic-Milacic, Marija, 2023-10-02 [InstanceEdit:9965916] Stephan, Ralf, 2025-09-08 [InstanceEdit:9965929] Orlic-Milacic, Marija, 2025-09-08 [InstanceEdit:9965933] Orlic-Milacic, Marija, 2025-09-08 [InstanceEdit:9966086] Stephan, Ralf, 2025-09-10 |
| text | DIO2 gene encodes type II iodothyronine deiodinase, which is essential for adaptive thermogenesis in brown adipose tissue, as one of the regulators of the adaptive thermogenesis is the thyroid hormone T3 (3,5,3’-triiodothyronine). Based entirely on different mouse studies cited below DIO2 gene is annotated as a candidate EBF2 target gene, as direct binding of EBF2 to the regulatory regions of this gene has not been reported. EBF2 promotes DIO2 gene expression in white adipocytes during their transition to beige adipocytes (Rajakumari et al. 2013), while knockdown of EBF2 mRNA in beige adipocytes leads to downregulation of DIO2 (Pearson et al. 2019). Upregulation of Blnc1, a lncRNA that interacts with the transcription factor EBF2 and stimulates EBF2-mediated induction of genes involved in beige and brown adipogenesis, is associated with upregulation of DIO2 mRNA expression (Zhao et al. 2014; Mi et al. 2017). Depletion of DPF3, a subunit of the BAF chromatin remodeling complex that binds EBF2 and promotes transcription of EBF2 target genes, leads to downregulation of DIO2 mRNA (Shapira et al. 2017). Ectopic overexpression of ID1, which was reported to bind to and negatively regulate EBF2, leads to reduced DIO2 expression (Patil et al. 2017). ZNF423, an inhibitor of EBF2 transcriptional activity, represses DIO2 gene expression (Shao et al. 2016; Shao et al. 2021) and the repression is dependent on the ability of ZNF423 to interact with the NuRD transcriptional repressor complex (Shao et al. 2021). |
| (summation) | [BlackBoxEvent:9844598] DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423 [Homo sapiens] |
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No pathways have been reviewed or authored by DIO2 gene encodes type II iodothyronine deiodinase, which is... (9844649)
