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Details on Person Based on mouse studies, Cidea a candidate Ebf2 target gene, ...
| Class:Id | Summation:9844632 |
|---|---|
| _displayName | Based on mouse studies, Cidea a candidate Ebf2 target gene, ... |
| _timestamp | 2023-10-02 20:48:02 |
| created | [InstanceEdit:9844633] Orlic-Milacic, Marija, 2023-09-21 |
| modified | [InstanceEdit:9844651] Orlic-Milacic, Marija, 2023-09-21 [InstanceEdit:9844780] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9844899] Orlic-Milacic, Marija, 2023-09-23 [InstanceEdit:9845456] Orlic-Milacic, Marija, 2023-10-02 |
| text | Based on mouse studies, Cidea a candidate Ebf2 target gene, as no direct binding of Ebf2 to the Cidea gene regulatory sequences has been reported. Ebf2 stimulates expression of the Cidea gene, while targeted Ebf2 knockout in mouse brown fat tissue results in severely reduced expression of the Cidea gene (Rajakumari et al. 2013; Wang et al. 2014). Ebf2 promotes Cidea gene expression in mouse beige adipocytes (Stine et al. 2016), while knockdown of Ebf2 mRNA in beige adipocytes leads to downregulation of Cidea (Pearson et al. 2019). Knockdown of Blnc1, a lncRNA that interacts with the transcription factor Ebf2 and stimulates Ebf2-mediated induction of gene involved in beige and brown adipogenesis, leads to downregulation of Cidea mRNA in mouse brown preadipocytes, while Blnc1-transduced mouse preadipocytes show upregulation of Cidea mRNA (Zhao et al. 2014). Ebf2 is required for the formation of the activating histone mark H3K27ac on the Cidea gene and RNA Pol II recruitment (Shapira et al. 2017). Mll4 complex is required for the formation of the super-enhancer at the Cidea gene locus (Lai et al. 2017), with ChIP-seq showing that Pparg binding sites in the CIDEA gene co-localize with H3K4me1 and H3K27ac marks of active chromatin (Brunmeir et al. 2016). The transcription factor Six1, which directly interacts with Ebf2, co-localizes with Pparg and activating histone marks at the Cidea gene enhancer and is able to induce Cidea gene transcription (Brunmeir et al. 2016). Znf423, an inhibitor of Ebf2 transcriptional activity, represses Cidea gene expression and the repression is dependent on the ability of Znf423 to interact with the NuRD transcriptional repressor complex (Shao et al. 2021). |
| (summation) | [BlackBoxEvent:9844626] Cidea gene expression is stimulated by Ebf2 and Pparg and repressed by Znf423 and NuRD [Mus musculus] |
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No pathways have been reviewed or authored by Based on mouse studies, Cidea a candidate Ebf2 target gene, ... (9844632)
