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Details on Person DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423

Class:Id	BlackBoxEvent:9844598
_displayName	DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423
_doRelease	TRUE
_timestamp	2025-09-25 08:25:03
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9844599] Orlic-Milacic, Marija, 2023-09-21
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
inferredFrom	[BlackBoxEvent:9844655] Dio2 gene expression is stimulated by Ebf2 and repressed by Znf423 and NuRD [Mus musculus]
input	[EntityWithAccessionedSequence:9844468] DIO2 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9845460] Rothfels, Karen, 2023-09-29 [InstanceEdit:9845461] May, Bruce, 2023-10-01 [InstanceEdit:9967044] D'Eustachio, Peter, 2025-09-25
isChimeric	FALSE
modified	[InstanceEdit:9844651] Orlic-Milacic, Marija, 2023-09-21 [InstanceEdit:9844658] Orlic-Milacic, Marija, 2023-09-21 [InstanceEdit:9845466] Orlic-Milacic, Marija, 2023-10-03 [InstanceEdit:9854563] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855095] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855221] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9863215] Orlic-Milacic, Marija, 2024-02-27 [InstanceEdit:9965916] Stephan, Ralf, 2025-09-08 [InstanceEdit:9966041] Orlic-Milacic, Marija, 2025-09-09 [InstanceEdit:9966045] Orlic-Milacic, Marija, 2025-09-09 [InstanceEdit:9966086] Stephan, Ralf, 2025-09-10 [InstanceEdit:9967043] Stephan, Ralf, 2025-09-25
name	DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423
output	[EntityWithAccessionedSequence:9966037] DIO2 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9844360] EBF2 binds Blnc1 lncRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:9844628] Positive regulation by 'EBF2,EBF2:Blnc1 lncRNA:HNRNPU [nucleoplasm]' [NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]' [NegativeRegulation:9844624] Negative regulation by 'ZNF423 [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9844602] R-HSA-9844598.2
structureModified	[InstanceEdit:9844651] Orlic-Milacic, Marija, 2023-09-21 [InstanceEdit:9965916] Stephan, Ralf, 2025-09-08 [InstanceEdit:9966041] Orlic-Milacic, Marija, 2025-09-09 [InstanceEdit:9966045] Orlic-Milacic, Marija, 2025-09-09
summation	[Summation:9844649] DIO2 gene encodes type II iodothyronine deiodinase, which is...
(hasEvent)	[Pathway:9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 [Homo sapiens] [Pathway:9962042] NEW: Regulation of thyroid hormone activity [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9966042] DIO2 mRNA translation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971953] Update Tracker - [BlackBoxEvent:9844598] DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423 - v95:[add_removeOutput, modifyText]
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