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Details on Person Ucp1 gene expression is stimulated by Ebf2 and Pparg and repressed by Znf423 and NuRD

Class:Id	BlackBoxEvent:9844554
_displayName	Ucp1 gene expression is stimulated by Ebf2 and Pparg and repressed by Znf423 and NuRD
_doRelease	TRUE
_timestamp	2024-03-06 02:46:11
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9844555] Orlic-Milacic, Marija, 2023-09-19
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
input	[EntityWithAccessionedSequence:9854596] Ucp1 gene [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9844394] ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes [LiteratureReference:9844390] Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program [LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex [LiteratureReference:9844613] Ebf2 is a selective marker of brown and beige adipogenic precursor cells [LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation [LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation [LiteratureReference:9844614] EBF2 promotes the recruitment of beige adipocytes in white adipose tissue [LiteratureReference:9828141] MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
modified	[InstanceEdit:9844811] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9844817] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9854542] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855011] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9855222] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9863933] Matthews, Lisa, 2024-03-06
name	Ucp1 gene expression is stimulated by Ebf2 and Pparg and repressed by Znf423 and NuRD
output	[EntityWithAccessionedSequence:9855002] Ucp1 [mitochondrial inner membrane] [Mus musculus]
regulatedBy	[NegativeGeneExpressionRegulation:9855001] Negative gene expression regulation by 'NuRD:Znf423:Ebf2,Ebf2:Blnc1 lncRNA:Hnrnpu:Ucp1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9855003] Positive gene expression regulation by 'Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu, Activated Pparg:Rxra:Ucp1 gene [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863934] Chun, Tae-Hwa, 2023-12-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9844556] R-MMU-9844554.1
structureModified	[InstanceEdit:9855011] Orlic-Milacic, Marija, 2023-11-29
summation	[Summation:9844812] In mouse brown adipocyte lineage Ucp1 gene is directly trans...
(inferredFrom)	[BlackBoxEvent:9844549] UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD [Homo sapiens]
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