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Details on Person UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD

Class:Id	BlackBoxEvent:9844549
_displayName	UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD
_doRelease	TRUE
_timestamp	2024-02-27 23:47:30
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9844550] Orlic-Milacic, Marija, 2023-09-19
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
inferredFrom	[BlackBoxEvent:9844554] Ucp1 gene expression is stimulated by Ebf2 and Pparg and repressed by Znf423 and NuRD [Mus musculus]
input	[EntityWithAccessionedSequence:9843798] UCP1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9845460] Rothfels, Karen, 2023-09-29 [InstanceEdit:9845461] May, Bruce, 2023-10-01
isChimeric	FALSE
modified	[InstanceEdit:9844557] Orlic-Milacic, Marija, 2023-09-19 [InstanceEdit:9844811] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9844817] Orlic-Milacic, Marija, 2023-09-22 [InstanceEdit:9845477] Orlic-Milacic, Marija, 2023-10-03 [InstanceEdit:9854543] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855221] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9863215] Orlic-Milacic, Marija, 2024-02-27
name	UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD
output	[EntityWithAccessionedSequence:166394] UCP1 [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:9844438] ZNF423 recruits NuRD to EBF2 target genes [Homo sapiens] [Reaction:9844375] ZNF423 binds EBF2 at EBF2-target gene loci [Homo sapiens] [Reaction:9844366] EBF2 binds target gene loci [Homo sapiens] [Reaction:9844360] EBF2 binds Blnc1 lncRNA [Homo sapiens] [BlackBoxEvent:9844440] PPARG binds EBF2-bound gene loci [Homo sapiens] [Reaction:9844366] EBF2 binds target gene loci [Homo sapiens] [BlackBoxEvent:9844822] PPARGC1A gene expression is stimulated by EBF2 [Homo sapiens] [BlackBoxEvent:9843832] ZNF516 and PRDM16 stimulate PPARGC1A gene expression [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:9844551] Negative gene expression regulation by 'NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9844813] Positive gene expression regulation by 'EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:UCP1 gene [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9844552] R-HSA-9844549.1
structureModified	[InstanceEdit:9844817] Orlic-Milacic, Marija, 2023-09-22
summation	[Summation:9844810] UCP1 gene encodes mitochondrial brown fat uncoupling protein...
(hasEvent)	[Pathway:9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 [Homo sapiens]
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No pathways have been reviewed or authored by UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (9844549)