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Details on Person ZNF423 binds EBF2 at EBF2-target gene loci

Class:Id	Reaction:9844375
_displayName	ZNF423 binds EBF2 at EBF2-target gene loci
_doRelease	TRUE
_timestamp	2024-02-27 23:47:34
authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9844374] Orlic-Milacic, Marija, 2023-09-16
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
inferredFrom	[Reaction:9844373] Znf423 binds Ebf2 at Ebf2-target gene loci [Mus musculus]
input	[EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3222318] ZNF423 [nucleoplasm] [Homo sapiens] [CandidateSet:9844503] EBF2, EBF2:Blnc1 lncRNA:HNRNPU: PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene) [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9845460] Rothfels, Karen, 2023-09-29 [InstanceEdit:9845461] May, Bruce, 2023-10-01
isChimeric	FALSE
modified	[InstanceEdit:9844420] Orlic-Milacic, Marija, 2023-09-16 [InstanceEdit:9844434] Orlic-Milacic, Marija, 2023-09-16 [InstanceEdit:9844446] Orlic-Milacic, Marija, 2023-09-17 [InstanceEdit:9844450] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9844459] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9844505] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9844524] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9845478] Orlic-Milacic, Marija, 2023-10-03 [InstanceEdit:9854541] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9854802] Orlic-Milacic, Marija, 2023-11-28 [InstanceEdit:9855221] Orlic-Milacic, Marija, 2023-11-29 [InstanceEdit:9863215] Orlic-Milacic, Marija, 2024-02-27
name	ZNF423 binds EBF2 at EBF2-target gene loci
output	[CandidateSet:9844412] ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9844366] EBF2 binds target gene loci [Homo sapiens] [Reaction:9844360] EBF2 binds Blnc1 lncRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9844429] Negative regulation by 'ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9844376] R-HSA-9844375.1
structureModified	[InstanceEdit:9844420] Orlic-Milacic, Marija, 2023-09-16 [InstanceEdit:9844434] Orlic-Milacic, Marija, 2023-09-16 [InstanceEdit:9844459] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9844505] Orlic-Milacic, Marija, 2023-09-18 [InstanceEdit:9854802] Orlic-Milacic, Marija, 2023-11-28
summation	[Summation:9844449] Based on studies in mice, the transcription factor ZNF423 (a...
(hasEvent)	[Pathway:9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9844415] PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 [Homo sapiens] [Reaction:9844438] ZNF423 recruits NuRD to EBF2 target genes [Homo sapiens]
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