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Details on Person SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)

Class:Id	Reaction:9844006
_displayName	SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
_doRelease	TRUE
_timestamp	2024-05-14 13:38:42
authored	[InstanceEdit:9843969] May, Bruce, 2023-09-11
catalystActivity	[CatalystActivity:9843992] histone H3 methyltransferase activity of me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9843957] May, Bruce, 2023-09-12
edited	[InstanceEdit:9843969] May, Bruce, 2023-09-11
input	[Complex:427402] Nucleosome [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9843984] Genome surveillance by HUSH-mediated silencing of intronless mobile elements
modified	[InstanceEdit:9844126] May, Bruce, 2023-09-12 [InstanceEdit:9851283] May, Bruce, 2023-10-16 [InstanceEdit:9909823] May, Bruce, 2024-05-14
name	SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
output	[Complex:5625748] Nucleosome with H3K9me3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9843993] me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA [Homo sapiens] [Reaction:9843990] HUSH complex binds LINE1 (L1) RNA [Homo sapiens] [Reaction:9844111] EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP [Homo sapiens]
releaseDate	2024-06-15
reviewed	[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14 [InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9844085] R-HSA-9844006.1
structureModified	[InstanceEdit:9844126] May, Bruce, 2023-09-12
summation	[Summation:9851271] SETDB1 tethered to retroelement nascent RNA via the HUSH com...
(hasEvent)	[Pathway:9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex [Homo sapiens]
(precedingEvent)	[Reaction:9844015] MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin [Homo sapiens]
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No pathways have been reviewed or authored by SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (9844006)