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Details on Person me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA

Class:Id	Reaction:9843993
_displayName	me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA
_doRelease	TRUE
_timestamp	2024-05-14 13:41:36
authored	[InstanceEdit:9843969] May, Bruce, 2023-09-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9843957] May, Bruce, 2023-09-12
edited	[InstanceEdit:9843969] May, Bruce, 2023-09-11
inferredFrom	[Reaction:9844103] me3-K16-Atf7ip binds Mphosph8 (Mpp8) [Mus musculus]
input	[Complex:9844013] HUSH complex:L1 RNA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9843973] MORC2 [nucleoplasm] [Homo sapiens] [Complex:9844105] me3-K16-ATF7IP:SETDB1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9843984] Genome surveillance by HUSH-mediated silencing of intronless mobile elements [LiteratureReference:9844027] Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2 [LiteratureReference:9909778] ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex [LiteratureReference:9844043] Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
modified	[InstanceEdit:9844126] May, Bruce, 2023-09-12 [InstanceEdit:9851283] May, Bruce, 2023-10-16 [InstanceEdit:9909823] May, Bruce, 2024-05-14
name	me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA
output	[Complex:9843959] me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9843990] HUSH complex binds LINE1 (L1) RNA [Homo sapiens] [Reaction:9844111] EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP [Homo sapiens]
releaseDate	2024-06-15
reviewed	[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14 [InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9844061] R-HSA-9843993.1
structureModified	[InstanceEdit:9844126] May, Bruce, 2023-09-12
summation	[Summation:9851280] The HUSH complex binds ATF7IP:SETDB1 (Timms et al. 2016) and...
(hasEvent)	[Pathway:9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex [Homo sapiens]
(precedingEvent)	[Reaction:9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) [Homo sapiens]
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No pathways have been reviewed or authored by me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (9843993)