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Query author contributions in Reactome

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Details on Person HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm]

Class:IdComplex:9843954
_displayNameHUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm]
_timestamp2023-12-23 21:20:37
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9843957] May, Bruce, 2023-09-12
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:9843922] GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
[LiteratureReference:9844043] Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
modified[InstanceEdit:9856839] May, Bruce, 2023-12-23
nameHUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9844079] R-HSA-9843954.1
(hasComponent)[Complex:9843933] me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] [Homo sapiens]
(input)[Reaction:9843927] me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin [Homo sapiens]
[Reaction:9844716] MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex [Homo sapiens]
(output)[Reaction:9844015] MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin [Homo sapiens]
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