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Details on Person FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex

Class:Id	BlackBoxEvent:9843900
_displayName	FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
_doRelease	TRUE
_timestamp	2025-11-04 02:55:53
authored	[InstanceEdit:9843898] Orlic-Milacic, Marija, 2023-09-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9843898] Orlic-Milacic, Marija, 2023-09-12
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
inferredFrom	[BlackBoxEvent:9843904] Fabp4 gene transcription is stimulated by Pparg:Rxra and Mll4,(Mll3) complex [Mus musculus]
input	[EntityWithAccessionedSequence:5640172] FABP4 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9907495] May, Bruce, 2024-04-10
isChimeric	FALSE
literatureReference	[LiteratureReference:9859790] White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways [LiteratureReference:2026052] PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes
modified	[InstanceEdit:9843908] Orlic-Milacic, Marija, 2023-09-12 [InstanceEdit:9851527] Orlic-Milacic, Marija, 2023-10-26 [InstanceEdit:9856184] Orlic-Milacic, Marija, 2023-12-13 [InstanceEdit:9856185] Orlic-Milacic, Marija, 2023-12-13 [InstanceEdit:9859584] Orlic-Milacic, Marija, 2024-01-21 [InstanceEdit:9859794] Orlic-Milacic, Marija, 2024-01-25 [InstanceEdit:9906660] Orlic-Milacic, Marija, 2024-04-01 [InstanceEdit:9907192] Orlic-Milacic, Marija, 2024-04-04 [InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9907535] Orlic-Milacic, Marija, 2024-04-12 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917919] Orlic-Milacic, Marija, 2024-08-13 [InstanceEdit:9971031] Orlic-Milacic, Marija, 2025-11-04
name	FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
output	[EntityWithAccessionedSequence:163428] FABP4 [lipid droplet] [Homo sapiens]
precedingEvent	[Reaction:9843119] MLL4-ASCOM,(MLL3-ASCOM) complex is recruited to ligand- and coactivator-bound PPARG:RXRA heterodimer [Homo sapiens] [BlackBoxEvent:9843120] Coactivators are recruited to liganded PPARG:RXRA heterodimer [Homo sapiens] [Reaction:9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex [Homo sapiens] [Reaction:9821410] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9851524] Positive gene expression regulation by 'Activated PPARG:RXRA:FABP4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm]'
releaseDate	2024-09-11
reviewed	[InstanceEdit:9970975] Aberin, Marvin Angelo E, 2025-10-31 [InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9843902] R-HSA-9843900.2
structureModified	[InstanceEdit:9851527] Orlic-Milacic, Marija, 2023-10-26
summation	[Summation:9843896] Expression of the FABP4 gene, encoding Fatty acid-binding pr...
(hasEvent)	[Pathway:9841922] MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971813] Update Tracker - [BlackBoxEvent:9843900] FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex - v95:[modifyText]
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