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Details on Person Based on studies in mice, transcription factors ZNF516 and P...
| Class:Id | Summation:9843809 |
|---|---|
| _displayName | Based on studies in mice, transcription factors ZNF516 and P... |
| _timestamp | 2023-09-12 09:42:31 |
| created | [InstanceEdit:9843811] Orlic-Milacic, Marija, 2023-09-12 |
| literatureReference | [LiteratureReference:9843787] Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat [LiteratureReference:9843754] Control of brown and beige fat development |
| text | Based on studies in mice, transcription factors ZNF516 and PRDM16, which are able to form a complex, directly stimulate transcription of UCP1 gene in response to noradrenergic signaling triggered by exposure to cold (Dempersmier et al. 2015). UCP1 gene encodes Ucoupling protein 1, specifically expressed in the mitochondrial inner membrane of brown and beige adipocytes. UCP1 uncouples oxidative respiration from ATP synthesis, allowing for the released chemical energy to dissipate as heat (reviewed in Wang and Seale 2016). |
| (summation) | [BlackBoxEvent:9843810] ZNF516 and PRDM16 stimulate UCP1 gene expression [Homo sapiens] |
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No pathways have been reviewed or authored by Based on studies in mice, transcription factors ZNF516 and P... (9843809)
