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Details on Person ABCC1,ABCG2 transport C18-S1P to extracellular region

Class:Id	Reaction:9843721
_displayName	ABCC1,ABCG2 transport C18-S1P to extracellular region
_doRelease	TRUE
_timestamp	2025-01-29 08:52:55
authored	[InstanceEdit:9843718] Stephan, Ralf, 2023-09-09
catalystActivity	[CatalystActivity:9843728] sphingolipid intramembrane carrier activity of ABCC1,ABCG2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9843723] Stephan, Ralf, 2023-09-10
edited	[InstanceEdit:9851336] Stephan, Ralf, 2023-10-23
input	[SimpleEntity:428203] C18-S1P [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[URL:9843698] https://doi.org/10.3934/MOLSCI.2014.4.183 [LiteratureReference:9843734] Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2 [LiteratureReference:9843719] Role of ABCC1 in export of sphingosine-1-phosphate from mast cells [LiteratureReference:9843730] Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone
modified	[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851343] Stephan, Ralf, 2023-10-24 [InstanceEdit:9851350] Stephan, Ralf, 2023-10-24 [InstanceEdit:9851351] Stephan, Ralf, 2023-10-24 [InstanceEdit:9937068] Stephan, Ralf, 2025-01-29
name	ABCC1,ABCG2 transport C18-S1P to extracellular region
output	[SimpleEntity:419305] C18-S1P [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens] [Reaction:428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate [Homo sapiens] [Reaction:428123] KDSR reduces 3-ketosphingoid [Homo sapiens] [Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) [Homo sapiens] [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens] [Reaction:428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate [Homo sapiens] [Reaction:428123] KDSR reduces 3-ketosphingoid [Homo sapiens] [Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9843739] R-HSA-9843721.2
summation	[Summation:9843729] The proton pumps ABCC1, ABCG2 transport sphing-4-enine 1-pho...
(hasEvent)	[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate [Homo sapiens]
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No pathways have been reviewed or authored by ABCC1,ABCG2 transport C18-S1P to extracellular region (9843721)